Chris Rock made a joke about Jada Pinkett Smith's shaved head, which did not appear to go over well with her husband Will Smith, CNN reported.
While presenting the award for best documentary, Rock joked, "Jada I love you, 'G.I. Jane 2,' can't wait to see it."
The camera cut to Pinkett Smith, who rolled her eyes as she sat next to Smith.
"That was a nice one," Rock said, appearing to respond to the joke not going over well.
Pinkett Smith has been open about her struggle with alopecia, an autoimmune disorder that leads to hair loss.
Rock then said, "Oh uh," and laughed as Smith walked toward him on stage and appeared to strike Rock in the face.
According to CNN reporter Stephanie Elam, who is in the audience, she could hear Rock getting hit. Smith said twice during the incident, according to Elam, "Keep my wife's name out of your f***ing mouth!"
Rock responded: "Oh, wow."
For viewers at home, censors muted the verbal part of the exchange between Rock and Smith.
The theater went silent and Rock said, "That was the greatest night in the history of television."
Sean "Diddy" Combs took to the stage moments later and told Smith and Rock that they would settle things "like family" later.
Photo by Getty Images
23:26, November 27Antonio Banderas names his ideal candidate for role of new Zorro
20:18, November 27‘Wednesday’ series’ co-creator hints about 2nd season
17:26, November 27Shakira intends to stand trial
15:13, November 27GQ names Bella Hadid world’s most stylish celebrity
13:21, November 27Brawl erupts between rapper Headie One and a rival at Sony Music HQ in London
11:24, November 27'Strange World' scores Disney animation's worst CinemaScore
10:13, November 27Queen Elizabeth's biographer puts forward new theory for her death
23:21, November 26Amber Heard tops list of most popular celebrities in Google searches
16:16, November 26Jennifer Lopez announces first album since 2014
12:12, November 26Lost treasure. Deleted scenes of ‘Iron Man 2’
10:14, November 26Alessandro Michele resigns as Gucci creative director
18:01, November 2578-year-old Squid Game actor Oh Young-soo accused of sexual harassment