Chris Rock made a joke about Jada Pinkett Smith's shaved head, which did not appear to go over well with her husband Will Smith, CNN reported.
While presenting the award for best documentary, Rock joked, "Jada I love you, 'G.I. Jane 2,' can't wait to see it."
The camera cut to Pinkett Smith, who rolled her eyes as she sat next to Smith.
"That was a nice one," Rock said, appearing to respond to the joke not going over well.
Pinkett Smith has been open about her struggle with alopecia, an autoimmune disorder that leads to hair loss.
Rock then said, "Oh uh," and laughed as Smith walked toward him on stage and appeared to strike Rock in the face.
According to CNN reporter Stephanie Elam, who is in the audience, she could hear Rock getting hit. Smith said twice during the incident, according to Elam, "Keep my wife's name out of your f***ing mouth!"
Rock responded: "Oh, wow."
For viewers at home, censors muted the verbal part of the exchange between Rock and Smith.
The theater went silent and Rock said, "That was the greatest night in the history of television."
Sean "Diddy" Combs took to the stage moments later and told Smith and Rock that they would settle things "like family" later.
Photo by Getty Images
17:19, December 6Tamzin Merchant breaks silence on playing Daenerys in original Game of Thrones pilot
11:15, December 6“The Mud” by Vahan Grigoryan was showcased in New York and London during the AGBU Arts “Armenians in Film” screenings
22:35, December 4Florence Pugh Hit By Audience-Thrown Object At 'Dune 2' Event In Brazil
16:25, December 4Taylor Swift generates more than $100M in spotify streaming revenue this year
14:53, December 4
House of the Dragon’ Season 2 Teaser Trailer Shows Intense Dragon War Action
14:15, December 3Julia Roberts reveals what iconic 90s movie Pretty Woman was really meant to be about
15:17, November 29Kendall Jenner becomes third KarJenner to land Forbes cover after Kim Kardashian and Kylie Jenner
14:29, November 29Michael Douglas gets lifetime achievement award at International Film Festival of India in Goa
22:26, November 27Angelina Jolie and Brad Pitt's adopted son Pax called his father a 'despicable person' who makes his four youngest children 'tremble in fear' in explosive Instagram rant
15:23, November 27Taylor Swift invites the family of Ana Clara Benevides Machado - the 23-year-old Swiftie who tragically died before the Rio show - to her Eras Tour performance in Sao Paolo
22:12, November 20Justin Timberlake reportedly considering legal action against ex-girlfriend Britney Spears
13:35, November 20Shakira to appear in Barcelona court on the first day of her tax fraud trial in Spain